Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade (ICB)
immunotherapy have recently emerged as a breakthrough in human cancer treatment. …

… The TNF-α mRNA level was also elevated in spleen tissue from the IκBα J/J pups, but this
elevation was also seen in the spleens of the IκBα +/J and +/+ animals and therefore was not …

The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …

Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the
skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 …

Type XIV collagen is a fibril-associated collagen with an interrupted triple helix. This collagen
interacts with the fibril surface and has been implicated as a regulator of fibrillogenesis; …

… In this issue of the JCI, Klement and colleagues describe an additional pathway of T cell
inhibition in cancer. Specifically, the authors demonstrate that downregulation of IRF8, a …

The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids
in the outermost epidermal layers and is essential for skin barrier function. Involucrin, …

… Männikkö and JF Klement, unpublished observations). Furthermore, intraperitoneal injections
of Ringer’s lactate/dextrose solution have been able to extend the life of the affected mice …

Background This is the first study to experimentally explore the direct relationship between
circulating VEGF levels and body mass index (BMI) as well as to unravel the role of insulin …

… A growing body of research shows that the biggest impact on our risk preferences comes
from our experiences and the environment we interact with (eg, Klement and Miranda 2012). …