… was 8.9 μmol/L, a value lower than the theoretical ED 50 (20.1 μmol/L) produced by … L (median
287.7 μg/L), with the MEC for the M1 metabolite being 0.9 to 190.5 μg/L (median 36.2 μg/L…

… Scott's choice of diyne 32 as a precursor to corannulene (1) was predicated on two … striking
first validation of the strategy that Scott had envisioned for preparing geodesic polyarenes by …

Introduction Precision medicine methodologies and approaches have advanced our
understanding of the clinical presentation, development, progression, and management of …

The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves.
The first was associated with a mix of SARS-CoV-2 lineages, while the second and third …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …

Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa’s fourth …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

… We used 1 μmol/L of a common reverse primer and 0·5 μmol/L of two forward primers (panel).
The first forward primer is specific for the mutant allele and contains an intentional …

… L 1 (X 1 ), ..., L 1 (X 8 )), we fold them to get the left probabilities of the reduced state space at
marker 1: ℒ 1 (Y 1 ), ℒ 1 (Y 2 ), and ℒ … to marker 6 to get ℒ 6 (Y 1 ), ℒ 6 (Y 2 ), and ℒ 6 (Y 3 ). …