[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction

…, S Attaluri, B Shuai, DLG Gitai, S Rao… - Brain, behavior, and …, 2023 - Elsevier
… Tukey’s posthoc tests revealed statistically significant differences between naïve and TBI
groups and TBI and TBI + EVs groups for the total NF-kB but not for the NF-kB p65 (Fig. 4 [EF]). …

Profile hidden Markov models and metamorphic virus detection

S Attaluri, S McGhee, M Stamp - Journal in computer virology, 2009 - Springer
… For simplicity, we have chosen to use Prim’s algorithm [29] to … that the use of Prim’s algorithm
does not appear to create any … , the spanning tree was constructed using Prim’s algorithm. …

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

M Kodali, S Attaluri, LN Madhu, B Shuai… - Aging …, 2021 - Wiley Online Library
Metformin, a drug widely used for treating diabetes, can prolong the lifespan in several
species. Metformin also has the promise to slow down age‐related cognitive impairment. …

Advances in sweetpotato breeding from 1992 to 2012

…, M Hossain, E Rahaman, SI Attaluri… - … and sweetpotato in …, 2015 - cabidigitallibrary.org
Sweetpotato, with a global annual planting area of approximately 9 million ha, is the second
most important tropical root crop. It is widely adapted, being grown in more than 110 …

Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties

R Upadhya, LN Madhu, S Attaluri… - Journal of …, 2020 - Taylor & Francis
… and applied to S-Traps mini columns (Protifi, Farmingdale, NY, USA) for tryptic digestion (Promega,
Fitchburg, WI, USA) in 50 mM TEAB. Peptides were eluted from the S-Traps with 0.2…

[HTML][HTML] Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB …

LN Madhu, M Kodali, S Attaluri, B Shuai, L Melissari… - Redox Biology, 2021 - Elsevier
Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted
with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for …

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

…, B Shuai, M Kodali, S Attaluri… - Proceedings of the …, 2019 - National Acad Sciences
Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced
pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in …

[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles pervasively incorporate into neurons and microglia in both intact and status epilepticus …

…, DK Kim, A Thomas, B Shuai, S Attaluri… - International journal of …, 2019 - mdpi.com
… ], mediated neuroprotection in models of Parkinson’s disease [32] and ischemic-reperfusion …
Indeed, a communication exists between the nasal lymph compartment and the brain’s CSF …

[HTML][HTML] Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and …

…, D Upadhya, A Bates, S Attaluri… - Frontiers in molecular …, 2017 - frontiersin.org
… Service Inc., West Chester, PA, United States) were dissolved in 70% alcohol, at dosages
of 40 and 0.13 mg/kg, respectively, and applied dermally on the back of the animal’s neck. To …

Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood

LN Madhu, S Attaluri, M Kodali, B Shuai… - Brain, behavior, and …, 2019 - Elsevier
… We set an inclusion criterion that required at least 16 s of object exploration time in both
trials 2 and 3. Application of this criterion (ie, exploration of objects for ≥16 s in each of trials 2 …